| abstract |
The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) inhibitory activity, their stereoisomers or pharmaceutically acceptable salts thereof, their use for the preparation of therapeutic drugs, and pharmaceutical combinations comprising said compounds compounds, methods of using the compositions to treat disease, and methods of making the novel compounds. The novel compound of the present invention, its stereoisomer or pharmaceutically acceptable salt thereof has histone deacetylase (HDAC) inhibitory activity and can be effectively used for preventing or treating HDAC6-mediated diseases, including infectious diseases; Tumors; endocrine, nutritional, and metabolic disorders; mental and behavioral disorders; neurological disorders; ocular and adnexal disorders; cardiovascular disorders; respiratory disorders; digestive disorders; skin and subcutaneous tissue disorders; Deformities, deformations, and chromosomal abnormalities. |