http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108698989-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J23-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J23-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 |
| filingDate | 2017-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108698989-B |
| titleOfInvention | Process for the preparation of 1-methylpyrrolidin-3-ol |
| abstract | The present invention provides a process for the preparation of 1-methylpyrrolidin-3-ol on an industrial scale. A process for preparing a compound of formula (I), comprising: step A: reacting a compound represented by formula (II) with formaldehyde and hydrogen in the presence of a metal catalyst in a solvent, wherein the amount of formaldehyde used is more than 1 mole and not more than 5 moles with respect to 1 mole of the compound represented by formula (II), thereby obtaining a mixture comprising formaldehyde and the compound represented by formula (I); and, step B: mixing a mixture comprising formaldehyde and the compound represented by formula (I) with hydrogen and a secondary amine selected from the group consisting of diethylamine, dipropylamine, diisopropylamine, butylethylamine, pyrrolidine, piperidine and morpholine in the presence of a metal catalyst in a solvent, and then removing the metal catalyst, followed by distillation to obtain the compound represented by formula (I). |
| priorityDate | 2016-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.