abstract |
The present invention relates to a kind of nitrogen-containing bicyclic compound and its preparation method and application. The compound or pharmaceutical composition can be used as an inhibitor of retinoic acid-related orphan receptor gamma t (Retinoid-related orphan receptor gamma t, RORγt). The present invention also relates to a method for preparing the compounds and pharmaceutical compositions, and their use in treating or preventing inflammation or autoimmune diseases mediated by RORγt in mammals, especially human beings. |