http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108675959-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 |
| filingDate | 2018-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108675959-B |
| titleOfInvention | Deuterated enrofloxacin-d5Preparation method of (1) |
| abstract | The invention discloses deuterated enrofloxacin- d 5 The preparation method comprises the step of adding 1-ethyl-piperazine- d 5 Performing Buchwald-Hartwig coupling reaction with 1-cyclopropyl-7-chloro-6-fluoro-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester to prepare 1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7- (4-ethyl-1-piperazinyl) -3-quinolinecarboxylic acid ethyl ester- d 5 (ii) a Then obtaining deuterated enrofloxacin-one-substituted by alkali hydrolysis d 5 . According to the preparation method, carboxylic acid groups are esterified and then are subjected to coupling reaction with ethylpiperazine, so that the synthetic reaction is easier to perform, the reaction difficulty is reduced, the product has very high yield, the isotopic abundance can be ensured under the high-temperature reaction condition, the reaction process is easier to control, the reproducibility and the stability are higher, and the condition of large-scale production is met. |
| priorityDate | 2018-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.