http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108671240-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8a483df1d4b5ea677dd937c512c750f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7c67b5e4336f39e1b1d17449f3488af8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate | 2018-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86bf373bc6e03b20cb58e3f5f62f84ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe700c018c30c6a95918a2e46b63c3c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_805b0f888a4620dbf092a40101b8a94b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7b7b73fcb383df5f62c0bd294ce2e82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18f28ab3c1b76e8a058ef1a5ad7672f9 |
| publicationDate | 2018-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108671240-A |
| titleOfInvention | A method of evaluation drug anti-liver injury drug effect |
| abstract | The invention discloses a kind of methods of evaluation drug anti-liver injury drug effect comprising step：A) measure administration before and administration after normal rat and liver injury model rat in different time periods serum in main pharmacodynamics ingredient concentration and with the relevant Biochemical Indices In Serum of hepatic injury；B) for selection medicine for marker, screening effect index establishes depression effect Sigmoid E max Model acquires pharmacodynamic parameter；C) according to Sigmoid E max Model can directly evaluate effect E=E of medicine effect to be measured max ﹣ (E max ﹣ E 0 )*(C γ /(C γ +EC 50 γ )), the pharmacodynamic parameter that step b is obtained is substituted into, corresponding effect E can be obtained for marker concentration C by measuring medicine.The present invention especially establishes pharmacodynamics model for marker as medicine using Paeoniflorin and albiflorin using serum tolal bile acid as effect index, can directly evaluate total glucoside drug anti-liver injury drug effect.This method need to only carry out Virus monitory, without to liver sampling analysis, more simple and effective. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115083622-A |
| priorityDate | 2018-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.