http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108671223-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
| filingDate | 2018-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108671223-B |
| titleOfInvention | Application of FHL3 in preparing medicament for treating insulin resistance |
| abstract | The invention relates to application of FHL3 in preparing a medicament for treating insulin resistance. Specifically, the invention relates to an application of FHL3 in preparing a medicament for regulating the expression of a glucose transporter GLUT4 in cells, and also relates to an application of a cell strain for stably expressing the FHL3 gene in preparing a medicament for treating insulin resistance. By over-expressing FHL3 at the cellular level, it was found that FHL3 inhibits uptake and utilization of glucose by mature myotubes and that the amount of glucose transporter expression is significantly reduced. FHL3 transgenic mice gained weight, insulin sensitivity decreased significantly, and simultaneously glucose tolerance was impaired. The functional research of the FHL3 has great application prospect and higher reference value in the development of the medicine for improving and treating the insulin resistance. |
| priorityDate | 2018-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 327.