http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108658999-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2018-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108658999-B |
| titleOfInvention | Synthesis method of 2-phenyl heterocyclic [2,3-d ] pyrimidine-4 (3H) -ketone compound |
| abstract | The invention discloses a synthesis method of a 2-phenyl heterocyclic [2,3-d ] pyrimidine-4 (3H) -ketone compound, which comprises the steps of utilizing carbon-carbon bond breakage of a styrene compound to generate a benzaldehyde compound, and carrying out intermolecular condensation coupling reaction on the generated benzaldehyde compound and a heterocyclic o-carbamamide compound to prepare the 2-phenyl heterocyclic [2,3-d ] pyrimidine-4 (3H) -ketone compound, wherein the styrene compound is as follows: styrene or 2-ethoxystyrene, and heterocyclic o-carbamamide compounds are: 3-aminothiophene-2-carboxamide or 4-amino-1-methyl-3-n-propyl-1H-pyrazole-5-carboxamide. The invention has the advantages that: the raw materials are cheap and easy to obtain, and are more economical; the reaction is efficient, and the yield is high; high temperature and high pressure are not needed, and the reaction condition is mild; the synthesis process is simple and convenient to operate, and the obtained product is easy to post-treat and suitable for large-scale industrial production. |
| priorityDate | 2018-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.