http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108658939-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2018-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108658939-B |
| titleOfInvention | A kind of synthetic method of key intermediate of dabigatran etexilate mesylate |
| abstract | The present invention relates to a kind of [2-[[(4-cyanophenyl)amino]-methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridine-2-yl)amino ] the synthetic method of ethyl propionate, reaction formula is as follows: It includes the following steps: 1) the compound SM01 reacts with the coupling reagent CDI in a toluene solution; 2) step 1) after the reaction is completed, the obtained reaction solution is cooled, and the toluene solution of SM02 is added to react; 3) after the reaction is completed, acetic acid is added , and continue to react to the end. Compared with the prior art, the synthetic method provided by the present invention uses a single solvent, does not need to replace the solvent in the middle of the reaction, is easy to operate, has few by-products, and has a high yield, with a yield of 93-96%, and is easy to obtain high-purity synthetic method. The product DB02, its HPLC content is above 99%. This method is suitable for industrial production. |
| priorityDate | 2018-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.