http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108658872-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-584 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-47 |
| filingDate | 2018-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108658872-B |
| titleOfInvention | Preparation method of avanafil intermediate |
| abstract | The invention provides a preparation method of an avanafil intermediate, which comprises the following steps: dissolving a starting material 4- (3-chloro-4-methoxybenzylamino) 5-ethoxycarbonyl-2-methylthiopyrimidine in a reaction solvent; adding metalloporphyrin as a catalyst, fully stirring to uniformly disperse, and transferring to a reaction kettle; introducing oxidizing gas at room temperature, and stirring for reaction to prepare 4- (3-chloro-4-methoxybenzylamino) 5-ethoxycarbonyl-2-methylsulfinylpyrimidine. The method takes substituted metalloporphyrin as a catalyst, takes air or oxygen as an oxidant, and catalytically oxidizes the thioether compound at normal temperature to prepare the sulfoxide intermediate of avanafil, and the target product and the catalyst are easy to separate after the reaction is finished. |
| priorityDate | 2018-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.