| abstract |
The invention relates to a method for reducing the residue of N-ethyl-3-phenylpropylamine in alverine, which belongs to a method for removing impurities of compounds. Dissolve the intermediate alverine crude product containing impurity N-ethyl-3-phenylpropylamine in a water-insoluble organic solvent, extract the organic layer with an aqueous solution of suitable pH, discard the aqueous layer; dry the organic layer, filter , Evaporate the solvent under reduced pressure. For the first time, the present invention provides a clear, simple, and reliable solution to the residual problem of the impurity N-ethyl-3-phenylpropylamine in the intermediate alverine, thereby ensuring that the subsequent production of the raw material citrate The alverine citrate has high quality, and the residual amount does not exceed 0.15%. The method is simple and easy, has low cost and less waste, and is suitable for industrial promotion. |