| abstract |
The invention provides, and in certain specific but non-limiting aspects, relates to: methods for modifying and/or improving ISV's so as to eliminate or reduce their propensity to produce said protein interference or said signal; - may Modifications introduced into ISVs that eliminate or reduce the propensity of said ISVs to produce said protein interferences or said signals; - are specifically selected (e.g., using the assays described herein) to have no or lower/reduced ISV's with a propensity to produce said protein interference or said signal; -modified and/or improved ISV's that do not have or have a lower/reduced propensity to produce said protein interference or said signal. |