http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108642119-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-40 |
| filingDate | 2018-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108642119-B |
| titleOfInvention | Method for resolution of 2- (4-methylphenyl) propionic acid enantiomer by stereoselective enzyme catalytic esterification |
| abstract | This patent describes a process for the catalytic esterification resolution of 2- (4-methylphenyl) propionic acid enantiomers using biocatalysts. Utilizing the high catalytic efficiency and high stereoselectivity of lipase to catalyze, esterify and resolve racemic 2- (4-methylphenyl) propionic acid in an organic solvent medium to prepare (S) -2- (4-methylphenyl) propionic acid. The reaction system uses an organic solvent system, improves the thermal stability and catalytic efficiency of lipase to a great extent, greatly improves the substrate conversion rate and optical activity, and ensures that the optical activity of the substrate is more than or equal to 97.84 percent. Compared with other resolution technologies, the method has the advantages of mild reaction conditions, simple operation and little environmental pollution, and can obtain the (S) -2- (4-methylphenyl) propionic acid with higher optical purity, which is used as a key intermediate, thereby providing a feasible method for preparing the loxoprofen sodium. |
| priorityDate | 2018-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 181.