http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108640931-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-18 |
| filingDate | 2018-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108640931-B |
| titleOfInvention | 7-ADCA crystal and preparation method thereof |
| abstract | The invention provides a 7-ADCA crystal and a preparation method thereof, wherein the X-ray powder diffraction pattern of the crystal is shown in figure 1, and the preparation method comprises the following steps: adding 7-ADCA into water, adding an alkali solution into the water, and adjusting the pH value to dissolve; adding alcohol to form a liquid to be crystallized of an alcohol/water mixed system; and adding acid into the liquid to be crystallized, adjusting the pH value to crystallize, continuously adding the acid until the pH value is = 3.8-4.0, carrying out solid-liquid separation, washing and drying the obtained solid, and thus obtaining the 7-ADCA crystal. The novel 7-ADCA crystal is prepared in an alcohol-water mixed solvent system, is easy to dissolve in a dichloromethane/tetramethylguanidine system, greatly improves the solubility of the 7-ADCA, is favorable for obtaining cephalosporin antibiotics with higher quality by taking the crystal as a raw material, and has wide industrial application prospect. |
| priorityDate | 2018-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.