http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108623804-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-48 |
| filingDate | 2018-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108623804-B |
| titleOfInvention | Preparation and application of amphiphilic polypeptide gene vector |
| abstract | The invention discloses a novel amphiphilic block polypeptide gene vector and application thereof, belonging to the technical field of nano-medical material preparation, wherein the method comprises the steps of initiating two polypeptide monomers of CBZ-L-lysine-NCA and L-leucine-NCA to carry out NCA ring-opening polymerization by using hexamethyldisilazane as an initiator, and finally removing a CBZ protective group to obtain the amphiphilic block polypeptide gene vector poly (L-lysine) 50 -b-poly (L-leucine) 15 (ii) a The polypeptide polymer has low toxicity, can compress plasmid DNA to assemble regular nano particles, has high transfection efficiency, and is an effective gene vector; in addition, the synthesis method of the invention is controllable polymerization, and the natural polypeptide is used as the raw material, so that the obtained polymer is safe and efficient. |
| priorityDate | 2018-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.