http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108623455-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-313 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-313 |
| filingDate | 2017-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108623455-B |
| titleOfInvention | Intermediate of anti-heart failure medicine |
| abstract | The invention discloses an intermediate of an anti-heart failure drug, which is shown as a compound in a formula IV. The intermediate takes malonate (formula VI) as raw material and sulfonyl protected ( R ) -lactate (formula VII) undergoes a nucleophilic substitution reaction to give a compound of formula V, which is then condensed with 4-biphenylacetyl chloride to give a compound of formula IV. The invention also discloses application of the compound shown in the formula IV, which is a key intermediate for preparing the compound shown in the formula I. Specifically, the compound of formula IV is subjected to decarboxylation to obtain a compound of formula III, and the compound of formula III is subjected to hydrolysis, salifying with organic amine and purification to obtain the compound of formula I. |
| priorityDate | 2017-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.