http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108623452-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68446a376bdbdc38d7fc1b41b394b55c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C61-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-353 |
| filingDate | 2018-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dbc5be03ef4c94feebc75371bcb212e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_415b7f0f8273b028baefe87b65a53191 |
| publicationDate | 2018-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108623452-A |
| titleOfInvention | A kind of synthetic method of intermediate S- (+) -2,2- dimethyl cyclopropane carboxylic acids |
| abstract | The invention discloses a kind of intermediate S (+) 2, the synthetic method of 2 dimethyl cyclopropane carboxylic acids, 2,2 dinethyl cyclopropane carboxylic acid methyl esters, NaOH, dichloromethane, (S) methyl mandelate, thionyl chloride, pyridine and N, N dimethylformamides be primary raw material, it is raw materials used according to the following ratio:2,2 dimethyl cyclopropane carboxylic acids and thionyl chloride mass ratio are 4：5；NaOH and H 2 O mass ratioes are 1：9；Pyridine, (S) methyl mandelate molar ratio are 1：1；The synthesis technology of the present invention uses 2; 2 dimethyl cyclopropane carboxylic acids and thionyl chloride occur acylation reaction and generate target product; a chiral salt is formed using chiral selectors (S) methyl mandelate and the substrate to be split; two kinds of configuration of compound are separated by recrystallizing, obtain the intermediate S (+) 2 of high-purity by the difference for recycling solubility; 2 dimethyl cyclopropane carboxylic acids; reaction condition is mild, and side reaction is few, and the yield of product greatly improves. |
| priorityDate | 2018-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.