http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108619511-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-145 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2018-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108619511-B |
| titleOfInvention | Preparation method and application of metal-organic framework drug-carrying system based on cytarabine small molecule prodrug |
| abstract | The invention discloses a preparation method and application of a metal-organic framework drug-carrying system of cytarabine prodrug. The invention selects molecules that can coordinate reaction with metal ions and covalently binds cytarabine to synthesize a novel Multifunctional small molecule prodrug, through a simple and environmentally friendly one-step encapsulation method, the prodrug is encapsulated in a metal organic framework to form drug-loaded nanoparticles, and after centrifugal washing and drying, a MOF loaded with cytarabine small molecule prodrug is obtained for intravenous injection preparation. Taking the synthesized Ara‑IR820@ZIF‑8 as an example, the antitumor pharmacodynamics results in mice showed that the HA/Ara‑IR820@ZIF‑8 nano-water solution had good antitumor effect and low systemic toxicity. The intravenous injection preparation has high drug loading capacity, simple and economical preparation process, can be mass-produced, and has low toxicity and good safety. In order to realize the high drug loading capacity of cytarabine in the metal-organic framework and to be used for intravenous administration of therapeutic entities tumor provides broad application prospects. |
| priorityDate | 2018-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.