| abstract |
The invention discloses a kind of Respiratory Syncytial Virus(RSV) epidemic meningitis combined vaccines, including：Intermediate is immunized in Respiratory Syncytial Virus(RSV), intermediate is immunized with meningococcus, the antigen that intermediate is immunized in the RSV is the RSV film surfaces fusion protein F and/or attachment protein G that can cause organism immune response, the nucleic acid sequence of wherein expression proteantigen is binned on nucleic acid carrier, and the nucleic acid sequence of recombinant protein is to be attenuated intracellular bacteria as bacteria carrier；It includes Δ fHbp, flexible connection peptide fragment and NadA that intermediate, which is immunized, in the meningococcus, the recombination Δ fHbp include fHbp can variant V1 VA, VB structural domain and fHbp can variant V3 VC, VD, VE structural domain；The immune intermediate of said components is prepared respectively, is faced with mixing. |