| abstract |
The invention discloses a kind of anti-Hib RSV meningococcus combined vaccines, the combined vaccine includes：Intermediate is immunized in Hib meningococcus intermediate and RSV, it includes modified Δ fHbp albumen, flexible connection peptide fragment and NadA albumen that intermediate, which is immunized, in the meningococcus, it is described recombination Δ fHbp albumen include fHbp can variant V1 VA, VB structural domain and fHbp can variant V3 VC, VD, VE structural domain, Hib capsular polysaccharides activate suffix together on Δ fHbp albumen and/or NadA albumen；The antigen that intermediate is immunized in the RSV is the RSV film surfaces fusion protein F and/or attachment protein G that can cause organism immune response, the nucleic acid sequence of wherein expression proteantigen is binned on nucleic acid carrier, and the nucleic acid sequence of recombinant protein is to be attenuated intracellular bacteria as bacteria carrier；The immune intermediate of said components is prepared respectively, is faced with mixing. |