http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108610345-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2018-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108610345-B |
| titleOfInvention | Synthesis method of benzimidazole [1,2-c ] quinazoline compound |
| abstract | The invention belongs to the technical field of compound synthesis, and particularly relates to benzimidazole [1,2- c ]A method for synthesizing quinazoline compounds. Under the alkaline condition, ultraviolet light is utilized to assist copper to catalyze 2- (2-halogen phenyl) benzimidazole and primary amine to firstly generate Ullmann coupling reaction, and then oxygen is used as an oxidant to carry out oxidation ring closing and oxidation dehydrogenation to form benzimidazole [1,2- c ]Quinazoline compounds. The method can be carried out at room temperature, wherein the molar ratio of 2- (2-halophenyl) benzimidazole to alkali to amine is 1:3 (1-3), and the dosage of the copper catalyst is 20 mmol%. Photocatalytic Ullmann of halogenated aromatic hydrocarbons in prior art N The arylation is carried out by using iodobenzene with higher activity, the report of carbon-hydrogen bond ammonium oxide is carried out under heating condition, and benzylamine is used. The invention breaks through the photocatalysis Ullmann of chloro-and fluoro-aromatic hydrocarbon N -arylation; in addition, the carbon-hydrogen bond oxidation amination reaction of the non-benzylamine lipoid fatty amine under photocatalysis is also broken through. |
| priorityDate | 2018-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.