http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108610341-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
| filingDate | 2018-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108610341-B |
| titleOfInvention | Mirtazapine synthesis and post-treatment method |
| abstract | The invention discloses a mirtazapine synthesis and post-treatment method, which comprises the following steps: (1) putting the milbeol into concentrated sulfuric acid in batches, and stirring for 8-16h at 20-30 ℃; (2) under the condition of stirring, putting the concentrated sulfuric acid reaction solution into a mixture of ice and methyl tert-butyl ether, and keeping reflux and condensation; (3) adding sodium hydroxide solution into the mixed solution to ensure that the pH value of the aqueous solution layer is more than 11, and keeping refluxing and condensing; (4) and (3) distilling the mixed solution under reduced pressure to remove the methyl tert-butyl ether solvent to obtain a mirtazapine crude product. According to the mirtazapine synthesis and post-treatment method provided by the invention, methyl tert-butyl ether is used as an extraction solvent, and even if concentrated sulfuric acid and sodium hydroxide are quickly added, the temperature can be effectively controlled, so that the generation of impurities is controlled, and the production efficiency is improved. |
| priorityDate | 2018-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.