http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108610306-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ec5284b467459bc08e01a5e2e123638 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D279-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D279-12 |
| filingDate | 2018-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd2168bcf28a513041b54ef3579d6388 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f4dd4a51638d5fb0bb7ac7a91e016b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a826816c07ceb4171f25cc5c49ea0e5c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_841fa7285822ea107b3fc848969050c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5ad450b374c7d1481fbc45dc91c3eea |
| publicationDate | 2018-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108610306-A |
| titleOfInvention | A kind of synthetic method of -3 (4H) -one derivative of 2H-1,4- thiazines |
| abstract | The present invention provides one kind 2 H 1,4 thiazines 3 (4 H ) ketone derivatives synthetic method, belong to organic synthesis field.This 2 H 1,4 thiazines 3 (4 H ) ketone derivatives synthetic method, will N 2 halogen acid amide of alkoxy, mercapto-acetaldehyde or its polymer are carried out reacting as the cyclization of form and hydroxyls dehydrate using sulfydryl substitution halogen, amido addition carbonyl successively by elder generation after.Reaction condition of the present invention is mild, easy to operate, and cyclization is dehydrated two-step reaction one kettle way and prepares 3 (4H) ketone of 2H Isosorbide-5-Nitraes thiazine, and reaction yield is higher；The raw material of reaction is easy to get, and prepared by 2 halogen acid amides convenient, and mercapto-acetaldehyde dimer is commercialized raw materials, and it is Conventional solvents to react used solvent, provides the pharmaceutical synthesis for 3 ketone compounds of Isosorbide-5-Nitrae thiazine and containing the structure to a kind of new method. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109879832-A |
| priorityDate | 2018-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.