http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108610293-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47d0c46a02d59ba47699c84801c25a1f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-16 |
| filingDate | 2018-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a85517f4066835ee095f26f6a254d5b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7449a1e94508892d3d0029e16cbb3da4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9308c22ed42ad53b3bd423e1a7a225c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2547db34cbd28c5f379e7c667ab49ef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f9b2684d6c34679aabe5c30924c87fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f14beee9a8d213429c6d1c956705b249 |
| publicationDate | 2018-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108610293-A |
| titleOfInvention | A kind of method adopting microchannel reaction device to prepare dovitinib intermediate |
| abstract | The invention discloses a method for preparing a dovitinib intermediate using a microchannel reaction device, comprising the following steps: (1) dissolving hydrochloric acid in ethanol to form a mixed solution, and mixing the mixed solution with 5-(4-methylpiperidine The ethanol solution of azinyl-1-base)-2-nitroaniline flows into the first microstructure reactor in the microchannel reaction device that is filled with zinc powder respectively and reacts simultaneously, obtains reaction effluent; (2) The reaction effluent that step (1) obtains and the ethanol solution of ethyl β-ethoxy-β-iminopropionate hydrochloride flow into the second microstructure reactor in the microchannel reaction device simultaneously and react respectively, and prepare Obtain ethyl-2-(6-(4-methylpiperazine-1-yl) benzimidazol-2-yl) ethyl acetate, which is the dovitinib intermediate. The method provided by the invention has few side reactions, high yield, simplified process steps, low production cost, and is more in line with the industrial standard of maximizing benefits. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113527263-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110746415-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109734702-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109734702-B |
| priorityDate | 2018-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.