| abstract |
The present invention relates to bifunctional compounds for use as modulators of targeted ubiquitination, in particular inhibitors of various polypeptides and other proteins which are degraded and/or otherwise inhibited by the bifunctional compounds according to the invention. Specifically, the present invention relates to compounds that contain at one end a VHL ligand that binds a ubiquitin ligase, and at the other end that binds a target protein so that the target protein is located in the vicinity of the ubiquitin ligase to enable the protein The degraded (and inhibited) part of the . The present invention exhibits a broad spectrum of pharmacological activity associated with the compounds according to the invention, consistent with the degradation/inhibition of the targeted polypeptide. |