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filingDate 2018-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-108588221-B
titleOfInvention Use of STIL gene and related medicine
abstract The invention provides an application of STIL gene and related drugs thereof. Discloses an application of the STIL gene in the preparation of a reagent or a kit for the auxiliary diagnosis or treatment/prognosis evaluation of nasopharyngeal carcinoma. Further discloses a small interfering RNA target segment of the STIL gene, small interfering RNA of the STIL gene, an RNA interfering nucleic acid construct of the STIL gene, an STIL gene interfering lentivirus, a pharmaceutical composition and a construction method of an RNA interfering lentivirus vector. The siRNA or the nucleic acid construct containing the siRNA sequence and the lentivirus provided by the invention can specifically inhibit the expression of the STIL gene, especially the lentivirus can efficiently infect target cells and efficiently inhibit the expression of the STIL gene in the target cells, so that the growth of tumor cells is inhibited, the apoptosis of the tumor cells is promoted, and the siRNA or the nucleic acid construct containing the siRNA sequence and the lentivirus have important significance in tumor treatment.
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