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filingDate 2018-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2020-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2020-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-108588034-B
titleOfInvention Variant rabbit viral hemorrhagic disease virus and application thereof in preparation of inactivated vaccine
abstract The invention provides a variant rabbit hemorrhagic disease virus and application thereof in preparing inactivated vaccine, wherein the strain is preserved in China center for type culture Collection, the preservation name is variant strain SH17 of the rabbit hemorrhagic disease virus, the preservation number is as follows: CCTCC NO: V201806. The strain has great difference in comparison with the sequence of the rabbit viral hemorrhagic disease virus separated at home at present, wherein the homology of the main antigen gene is only 80 percent. And the strain infects rabbits to be young, and the current rabbit viral hemorrhagic disease vaccine has no effective protective effect on the strain. Therefore, the invention provides the method for preparing the oil emulsion inactivated vaccine by using the rabbit viral hemorrhagic disease virus variant SH17 strain for the first time, the vaccine has good immune effect and small side effect on immunized rabbits, and the prepared vaccine has good antigenicity and high safety, has no adverse effect on the external environment and is easy to pass safety evaluation.
priorityDate 2018-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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