| abstract |
The invention discloses a synthesis method of a carbapenem antibiotic drug intermediate, using (R)-3-hydroxybutyrate as a raw material to prepare a carbapenem antibiotic drug intermediate 4‑AA, the route Raw materials are cheap and easy to get, and can be purchased in large quantities. The invention has simple steps, high yield of each step and simple reaction. The use of a chiral column to split a chiral center avoids the use of a noble metal chiral reduction catalyst, and the invention has the advantages of low cost, high yield and easy availability of reaction conditions. |