http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108586273-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-175 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-64 |
| filingDate | 2018-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108586273-B |
| titleOfInvention | Preparation method of propranolol hydrochloride |
| abstract | The invention belongs to the field of pharmaceutical chemicals, and particularly relates to a preparation method of propranolol hydrochloride, which comprises the following steps: step 1: reacting 1-naphthol with 1, 3-dibromo (iodo) acetone in sodium hydroxide solution to generate 1-bromo (iodo) -3- (1-naphthoxy) -2-acetone; step 2: reducing 1-bromo (iodo) -3- (1-naphthoxy) -2-propanone with sodium borohydride in an organic solvent to produce 1-bromo (iodo) -3- (1-naphthoxy) -2-propanol; and step 3: reacting 1-bromo (iodo) -3- (1-naphthoxy) -2-propanol with isopropylamine in an organic solvent to produce 1-isopropylamino-3- (1-naphthoxy) -2-propanol; and 4, step 4: the method avoids the use of epoxy chloropropane, is safer and more environment-friendly, does not have an intermediate containing an ethylene oxide structure in the reaction process, and has higher medication safety. |
| priorityDate | 2018-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.