http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108578420-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2018-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108578420-B |
| titleOfInvention | Application of luteolin in preparation of medicines for preventing and treating sepsis |
| abstract | The invention discloses application of luteolin in preparation of a medicament for preventing and treating sepsis. Animal experiments prove that on a sepsis mouse model induced by Cecal Ligation and Perforation (CLP), luteolin can remarkably reduce the death rate of a sepsis mouse, improve the survival rate, remarkably reduce the expression levels of early and late inflammatory factors TNF-alpha, IL-6 and HMGB1 in serum of the sepsis mouse, relieve the damage of the lung, the kidney and the liver of a target organ, and has an obvious sepsis prevention and treatment effect, and the sepsis-resistant effect of the luteolin is possibly closely related to the inhibition of MAPK and NF-kappa B signal pathways mediated by HMGB1, so that the compound can be further developed into a medicament for treating or preventing sepsis. |
| priorityDate | 2018-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 128.