| abstract |
The invention discloses a microcrystalline diketopiperazine composition and a method, and specifically discloses a DKP microcrystal prepared by an improved method, and the DKP microcrystal cannot irreversibly self-assemble into microparticles. The microcrystals can be dispersed by atomization and reformed into particles with spherical shell morphology by spray drying. Active agents and excipients can be incorporated into microcrystalline diketopiperazine particles by spray drying a solution containing the components to be incorporated into the particles. In particular, the microcrystalline particle composition is suitable for pulmonary drug delivery of one or more peptides, proteins, nucleic acids and/or small organic molecules. |