http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108570087-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2018-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108570087-B |
| titleOfInvention | Maleimide derivatives containing galactose triazole structure and its preparation method and application |
| abstract | The invention discloses a maleimide derivative containing galactose triazole structure and its preparation method and application. Firstly, N-p-hydroxyphenyl maleimide and acetylgalactose triazole salicylaldoxime are synthesized , and then N-p-hydroxyphenylmaleimide and acetylgalactose triazole salicylaldoxime were dissolved in absolute ethanol, and 1,3-dipolar cycloaddition reaction was carried out to introduce acetylgalactose triazole and Isoxazole structure, finally suspend the intermediate compound in methanol, slowly add methanol solution of sodium methoxide dropwise under the protection of nitrogen, heat to room temperature to continue the reaction, wash the ion exchange resin with methanol, remove methanol from the filtrate under reduced pressure to obtain a light yellow solid, Maleimide derivatives containing galactose triazole structure were separated by column chromatography. The maleimide derivatives containing the galactose triazole structure prepared by the invention have strong tumor cell inhibitory effect and provide a basis for further application in the field of medicine. |
| priorityDate | 2018-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.