http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108569987-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff89f3512ba2c471b8b2cb578ecb0904 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-40 |
| filingDate | 2017-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f99f5ddc8b898740f80ee3b031b82000 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37a982c276ae463520e6f14c4f587f08 |
| publicationDate | 2018-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108569987-A |
| titleOfInvention | A kind of synthesis technology of intermediate |
| abstract | The invention discloses a kind of synthesis technologies of intermediate, and this approach includes the following steps：Use dimethyl sulfoxide (DMSO) for solvent, it is separately added into 4 (methylsulfonyl amido) γ oxos phenylbutyric acids, 1 hydroxybenzotriazole and dicyclohexylcarbodiimide and ethylheptyl amine, after reaction solution is dissolved with chloroform, again successively through persalt, sodium bicarbonate, saturated common salt water washing, recycle organic solvent, crystallization is to get Ibolite fumarate intermediate.The present invention effectively avoids interference of the addition antioxidant to reaction process; the purity and quality of product are improved; and it is easy to large-scale production and control; production efficiency and safety are improved, the quality of product has been stabilized and increased, this method is easily operated; it isolates and purifies conveniently; product purity is more than 99%, and industrial pollution is few, is suitable for large-scale production. |
| priorityDate | 2017-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.