| abstract |
The invention discloses a preparation method of bromfenac sodium sesquihydrate. The method comprises the following steps: the compound of formula 3 undergoes a hydrolysis reaction with an aqueous solution of sodium hydroxide, and after the reaction is completed, the reaction liquid is directly sucked and filtered, and the filtrate is collected , add sodium chloride or sodium bicarbonate in the filtrate; After adding sodium chloride or sodium bicarbonate, the precipitated solid is washed with saturated brine and acetone, and then recrystallized using a mixed solvent, the mixed solvent being water/acetone, Water/ethylene glycol dimethyl ether, or water/ethylene glycol; the solid obtained by recrystallization is washed with acetone to obtain bromfenac sodium sesquihydrate, that is, the compound of formula 4. The preparation method of the invention has simple operation and stable process, and the prepared bromfenac sodium sesquihydrate product is a yellow solid with extremely high purity. |