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filingDate 2018-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2019-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2019-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-108567980-B
titleOfInvention The CO controllable delivery system and its construction method of light power induction
abstract The invention discloses the CO method for releasing of light power induction, CO controllable delivery system and its construction method.CO method for releasing of the invention under the irradiation of near infrared light, carries out the controlled release of CO by nearly infrared optical response type, the photosensitizer that can be used for optical dynamic therapy and carbon monoxide-releasing molecules CORM-401 mixing.The present invention is based on the CO method for releasing of light power induction, construct CO controllable delivery system, including near infrared light response type, it can be used for the photosensitizer of optical dynamic therapy, carbon monoxide-releasing molecules CORM-401, and load or the carrier for combining photosensitizer and carbon monoxide-releasing molecules CORM-401.CO controllable delivery system of the invention, the photochemical effect that near infrared light induction photosensitizer generates can promote CO controllable delivery system and enter cell, and nanogel disintegrates under the action of glutathione in the cell, releases CORM-401.Near infrared light activates while generating singlet oxygen and CO is respectively used to optical dynamic therapy and CO Gases for Treating, realizes combination therapy, and antitumous effect significantly improves.
priorityDate 2018-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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