http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108559766-B
Outgoing Links
Predicate | Object |
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classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P33-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-008 |
classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-365 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
filingDate | 2018-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2021-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-108559766-B |
titleOfInvention | Preparation method of steroid drug intermediate |
abstract | The invention relates to a preparation method of a steroid drug intermediate, which comprises the following steps: and carrying out microbial transformation on a first compound by using Nocardia simplex to obtain the steroid drug intermediate, wherein the first compound is shown as a general formula I, the steroid drug intermediate is shown as a general formula II, and R in the general formula I and the general formula II is H, a halogen atom, alkyl, alkoxy, hydroxyl or phenyl. The method selects 4,9(11) -pregna-17-hydroxy-3, 20-diketone-21-acetate as a substrate, only uses simple nocardia (Nocardioides simplex) to carry out biotransformation, carries out 1, 2-position dehydrogenation and 21-position acetate hydrolysis on the substrate simultaneously to obtain 1,4,9(11) -pregna-17, 21-diol-3, 20-diketone, most of products formed by transformation are 1,4,9(11) -pregna-17, 21-diol-3, 20-diketone, the proportion of byproducts is low, the purified products are white or white-like crystals, the yield is 75-85% relative to the weight of the substrate, the yield of target products is high, the purity is higher than or equal to 99% through HPLC analysis, and the content of external standard is higher than or equal to 99%>98%。 |
priorityDate | 2018-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.