http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108559748-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-16 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2018-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108559748-B |
| titleOfInvention | DNA aptamer specific to CD4 positive cell and chimera thereof |
| abstract | The invention discloses a DNA aptamer specific to CD4 positive cells and a chimera thereof. The invention combines the aptamer technology with the cell-oriented function and the RNAi technology to construct the DNA aptamer specific to the CD4 positive cell, so as to carry anticancer siRNA to be selectively introduced into the CD4 positive tumor-related macrophage. The DNA aptamer specific to the CD4 positive cell is detected in an in vitro tumor-associated macrophage and breast cancer cell culture system to serve as a carrier-oriented tool for conveying the function and the anti-tumor effect of the anti-cancer siRNA. The invention provides a novel gene anti-cancer drug based on guided RNAi and a new idea for researching and developing RNAi targeted introduction into target cells. |
| priorityDate | 2018-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 209.