http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108558890-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_31f7f4d0fc807c98c145cd77018bf2eb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2018-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a04a467e82ce11918fe4ce8ccf8179ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bebea089bdeef54fe5a640cdd86de034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6591ac0b3fdf51008bb81099f7cd7e5d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d50be711da41697b2ade6969ac3345b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cbe17d26fc0b8139df8268f49ac754d |
| publicationDate | 2018-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108558890-A |
| titleOfInvention | A kind of sildenafil intermediate synthetic method |
| abstract | Sildenafil has a good effect on treating male erectile dysfunction (ED) clinically. There are many reports on the preparation method of sildenafil. Most of them are two-step synthesis, and the two-step post-processing operation is relatively cumbersome, and the yield lower. The invention provides a method for synthesizing a sildenafil intermediate. Compound II is dissolved in an organic aprotic solvent, and compound I is added for condensation reaction; after the reaction of compound II is completed, a base is added for cyclization reaction to obtain compound IV. The invention adopts the "one-pot method" synthesis, reduces the generation of "three wastes", greatly shortens the reaction time, improves the reaction yield, and has good stability. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112608317-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111116591-A |
| priorityDate | 2018-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.