http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108558882-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-00 |
| filingDate | 2018-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108558882-B |
| titleOfInvention | Method for synthesizing chiral five-membered carbocyclic purine nucleoside through [3+2] cycloaddition based on allenoic acid ester |
| abstract | The invention discloses a method for synthesizing chiral five-membered carbocyclic purine nucleoside by [3+2] cycloaddition based on allenoic acid ester, belonging to the field of asymmetric synthesis in organic chemistry. α -purine-substituted acrylate 1 and allenoic acid ester 2 are used as raw materials, chiral STICP is used as a catalyst, chiral five-membered carbocyclic nucleoside 3 is obtained after reaction, the reaction enantioselectivity is good, the yield is medium to excellent, the chiral five-membered carbocyclic nucleoside 3 is reduced under the condition of sodium borohydride to obtain monoalcohol five-membered carbocyclic purine nucleoside 4, and then DIBA L-H is adopted for reduction to obtain diol five-membered carbocyclic purine nucleoside 5. |
| priorityDate | 2018-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.