http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108558723-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C337-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-53 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C337-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-53 |
| filingDate | 2018-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108558723-B |
| titleOfInvention | N- (2-isobornenyl) thiosemicarbazone compound and preparation method and application thereof |
| abstract | The invention discloses N - (2-isobornenyl) depsipeptidesThiosemicarbazide compounds, and preparation and application thereof. The invention uses camphene as raw material, and the camphene is sequentially subjected to addition reaction with potassium thiocyanate and hydrazine hydrate to obtain the catalyst N - (2-isobornenyl) thiosemicarbazide, and then carrying out condensation reaction with aromatic aldehyde with different substituents to obtain N - (2-isobornenyl) thiosemicarbazone compounds. The tests show that the above-mentioned material can be used, N - (2-isobornenyl) thiosemicarbazone compounds have very good anticancer activity, especially compound 4g, which has the best activity on MDA-MB-231 cells, IC 50 IC at 0.4116 μ M for A549 and RPMI-8226 cells 50 Also as low as 1.584. mu.M and 1.054. mu.M, as can be seen N The- (2-isobornenyl) thiosemicarbazone compound has good application value in the preparation of antitumor drugs. |
| priorityDate | 2018-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.