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filingDate 2018-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-108553644-B
titleOfInvention Double-valve multi-stimulus response type drug carrier constructed based on mesoporous silicon/cyclodextrin/zinc oxide quantum dots and preparation method thereof
abstract The invention discloses a 'double-valve' multi-stimulus response type drug carrier constructed based on mesoporous silicon/cyclodextrin/zinc oxide quantum dots and a preparation method thereof, wherein mesoporous silicon nano particles are used as carriers, and after drugs are loaded, aminated zinc oxide quantum dots are adopted for plugging to obtain a drug carrier plugged by the zinc oxide quantum dots; and then, connecting the obtained zinc oxide quantum dot blocked drug carrier with ferrocenecarboxylic acid through a chemical bond, and then reacting with the anhydride cyclodextrin to carry out secondary blocking to obtain the composite nano drug carrier system. The composite nano-drug carrier system has double pH sensitivity and H 2 O 2 The characteristics of oxidation sensitivity and fluorescence imaging, more efficient cancer cell targeting drug delivery capability and capability of effectively improving the utilization rate of drugs.
priorityDate 2018-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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