http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108553441-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2031 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 |
| filingDate | 2018-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108553441-B |
| titleOfInvention | A kind of Apixaban tablet and preparation method thereof |
| abstract | The invention discloses a kind of Apixaban tablets and preparation method thereof.The raw material of Apixaban tablet includes: 20-30 parts of Eliquis, 20-60 parts of HS-15,10-30 parts of PVP-K30,500-550 parts of lactose, 280-320 parts of microcrystalline cellulose, 45-55 parts of PVPP and coating pre-mixing agent 20-40 parts, wherein, HS-15 and PVP-K30 mass ratio are 4:1-1:3.Preparation method: 1) by Eliquis, HS-15, PVP-K30 dissolution in ethanol, clear solution is obtained；Again with spray drying, solid dispersions are obtained；2) solid dispersions are uniformly mixed direct tablet compressing with lactose, microcrystalline cellulose and PVPP, obtain plain piece；3) to plain piece be coated to get.The tablet can significantly improve the dissolution rate of drug, increase drug absorption, bioavilability be improved, so that the therapeutic effect of drug be enable to give full play to. |
| priorityDate | 2018-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.