| abstract |
The present invention provides a kind of antitumor medicine composition, described pharmaceutical composition includes Sorafenib and at least one iron preparation.Antitumor medicine composition provided by the invention inhibits SystemXc activity in Sorafenib, reduces intracellular GSH contents, under the premise of reducing cell reduced level, the iron preparation is added, because tumour cell has thermophilic iron characteristic, then can dramatically increase the Fe in tumour cell body 2+ Content, Fe 2+ Fenton's reaction is participated in, ROS is further generated, ROS can occur peroxidatic reaction of lipid with lipid and generate lipid ROS, can also cause protein and DNA damage, lead to the death of cell. |