http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108531514-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0041 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G83-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G83-00 |
| filingDate | 2018-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108531514-B |
| titleOfInvention | Endogenous hyperbranched polyspermine cationic gene vector and preparation method and application thereof |
| abstract | The invention discloses an endogenous hyperbranched polyspermine cationic gene vector and a preparation method and application thereof. The preparation method of the gene vector comprises the following steps: (1) dissolving endogenous monomers in an organic solvent, adding a protective agent under the anhydrous and anaerobic conditions, and stirring for reaction at the temperature of 20-30 ℃ to obtain protected endogenous monomers I; (2) dissolving an endogenous monomer I in water, adding a biodegradable linking agent, performing addition reaction at the temperature of 60-80 ℃, and adding diethyl ether to precipitate a product to obtain a polymer II; (3) adding a deprotection agent into the polymer II for reaction, filtering, freezing and drying to obtain the endogenous hyperbranched polyspermine cationic gene vector. The gene vector obtained in the invention has biodegradability and nontoxic metabolism, can aggregate and convey nucleic acid drugs, is compounded with the nucleic acid drugs, can obtain nano composite particles for treating DME, and realizes safe and efficient gene therapy. |
| priorityDate | 2018-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 226.