http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108531510-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0331 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate | 2018-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108531510-B |
| titleOfInvention | Application of transgenic zebra fish in preparation of animal model of chronic myelocytic leukemia |
| abstract | The invention discloses application of transgenic zebra fish in preparation of an animal model of chronic granulocytic leukemia. The transgenic zebra fish is BCR/ABL transgenic zebra fish and is humanized BCR-ABL induced transgenic zebra fish. When the humanized BCR/ABL mRNA is microinjected into zebra fish embryos, the embryos show a phenotype similar to chronic myelocytic leukemia: the large increase of neutrophils suggests that the human BCR/ABL protein can play a role in the body of the zebra fish; the invention discovers that the transgenic zebra fish has a phenotype similar to human leukemia in the juvenile and adult periods for the first time, and proves that the transgenic zebra fish can be used for high-throughput screening of drugs for treating leukemia, namely, the invention successfully establishes an animal model of chronic granulocytic leukemia and provides an effective way for the research of the chronic granulocytic leukemia and the drug screening thereof. |
| priorityDate | 2018-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.