| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fa3ec16ed83dfbed27964334a91dbcbb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-33 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70578
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70532
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7051 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
| filingDate |
2017-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71245161c0aae63b2d264a2c8424e6b6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a406ff07e3e08c86151abd76d8e5fe51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddbc816f73ced71c0fe5b6db7bab640f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f27dbc88c476e3fe7b334a0262816787
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b10c95152db844b077224da3d25fb41c |
| publicationDate |
2018-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-108530541-A |
| titleOfInvention |
A kind of recombination of Chimeric antigen receptor for CD22 is built and its application |
| abstract |
The present invention discloses structure and the application of a kind of third generation Chimeric antigen receptor gene for CD22 molecules.The recombinant protein of the antigen receptor gene code includes such as lower part：Extracellular region, by the series connection single chain variable fragment V for CD22 antigens H And V L It is formed with hinge area；Transmembrane region is originated from CD8 α；Intracellular region is made of with different permutation and combination methods tri- structures of ligand CD137 and CD80 of CD3 ζ and costimulatory molecules, is directly connected between three structures or is connected by Linker.By the third generation Chimeric antigen receptor gene fragment clone to plasmid vector, Lentiviral or retroviral vector, rotaring redyeing 293 cell system etc. is expanded, recombination is obtained after isolating and purifying, the T cell for transfecting from or separating in vivo is proliferated the CAR T cells being prepared to CD22 positive tumor cells with significant fragmentation effect after filtering out positive colony. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111254156-A |
| priorityDate |
2017-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |