| abstract |
The invention belongs to the technical field of medicinal chemistry, in particular to an amide arylpiperazine derivative, and further discloses a preparation method thereof and an application for preparing a medicine for treating benign prostatic hyperplasia. The amide arylpiperazine derivatives of the present invention and their pharmaceutically acceptable salts, through preliminary pharmacological studies, and biological function tests of isolated rat tissues (spleen, thoracic aorta, vas deferens), the derivatives α1A -AR and α1D -AR showed strong antagonistic activity and good selectivity, while the antagonistic ability of α1B subtype was weak, which could effectively reduce the side effects of the drug while ensuring the efficacy of the drug. It provides a more efficient and safe choice for the research and development of new anti-benign prostatic hyperplasia drugs. |