http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108524529-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F283-065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6907 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F8-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F283-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F230-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F8-32 |
| filingDate | 2018-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108524529-B |
| titleOfInvention | Acid-sensitive doxorubicin prodrug based on zwitterion and folic acid targeting and its preparation method and application |
| abstract | The invention discloses an acid-sensitive doxorubicin prodrug based on zwitterion and folic acid targeting, and a preparation method and application thereof. This kind of polyzwitterionic polymer prodrug FA-P(MPC- co -PEGMA-BZ) -g -DOX has better water solubility, better stability and biocompatibility. The structure of poly(2-methacryloyloxyethylphosphorylcholine) is similar to that of cell membranes, which facilitates the transmembrane transport of polymer prodrug micelles, promotes the endocytosis of polymer prodrug micelles, and improves the Utilization of prodrug micelles. In the slightly acidic environment of the tumor site, the Schiff base is broken, resulting in the rapid release of the doxorubicin original drug from the polymer prodrug micelles, thereby achieving the purpose of inhibiting tumor cell proliferation. The experimental conditions used in the present invention are relatively mild, the operation is simple, the raw materials are readily available, and the purification is easy, and is suitable for industrial production. Therefore, it can be used as a stimulus-sensitive antitumor prodrug, and has a great market application prospect in the future. |
| priorityDate | 2018-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.