| abstract |
The present invention relates to the field of medical technology, in particular to a gelling factor, a hydrogel and a pharmaceutical composition. The gelling factor has a sequence: Nap-Phe-Phe-Glu-Tyr-OH, and the specific structure is as follows: Among them, Nap is naphthyl, Phe is phenylalanine, Glu is glutamic acid, and Tyr is tyrosine. The hydrogel comprises a gel layer formed by tacrolimus and the above-mentioned gelling factors coated on its surface. The hydrogel formed by encapsulating tacrolimus after the gelling factor is gelled can disassemble and release tacrolimus when T cell activation and PTK content increase caused by immune rejection, thereby avoiding direct Taking tacrolimus can improve the therapeutic efficacy and greatly reduce the side effects of tacrolimus. |