| abstract |
The present invention relates to the method for tetrahydrobiopterin synthesis quinoline spiral shell cyclohexadienone framework compound, phenolic compound in the presence of hexafluoroisopropanol, undergoes α hydrogen migrations of nitrogen-atoms, finally obtains aromatization product with amino benzaldehyde compound.Synthetic method provided by the invention realizes the Hydrogen transfer reaction that driving force is turned to fragrance for the first time.Raw material is simple and easy to get；It can react at room temperature, reaction condition is mild, is not necessarily to metal or proton catalyst, easy to operate, economical and efficient；The reactivity of the method for the present invention is high, and yield is up to 98%, and raw material conversion is complete；Convenient product separation, and react with green economy, it is environmentally friendly. |