http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108503578-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-94 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-94 |
| filingDate | 2018-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108503578-B |
| titleOfInvention | Synthetic method of indeno- [1,2-b ] indole-10 (5H) -ketone compound |
| abstract | The invention relates to a synthetic method of indeno- [1,2-b ] indole-10 (5H) -ketone compounds. The synthesis method comprises the following steps: reacting the 3- (2-bromobenzoyl) -indole compound shown in the formula (1) with an alkyl lithium reagent, zinc halide and lithium halide to generate an indole zinc reagent shown in the formula (2), and then carrying out intramolecular coupling reaction to generate a target product. The synthesis method has the advantages that 3- (2-bromobenzoyl) -indole compounds react with alkyl lithium reagents, zinc halide and lithium halide, the exchange of halogen lithium is avoided through the selection of a substrate structure and a reaction reagent, the indole zinc reagent is generated on site, the coupling reaction is further carried out, and the indeno- [1,2-b ] indole-10 (5H) -ketone structure is efficiently constructed. The method avoids the use of expensive transition metal catalysts, has low cost and simple operation, and is convenient for large-scale industrial production. |
| priorityDate | 2018-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.